Ixabepilone 0160 It has minimal activity (IC50

It has minimal activity (IC50 >1 µM) against HDAC4

InChi: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

InChiKey: HRLQRNBAJCQMMG-UHFFFAOYSA-N

Obeticholic acid (INT-747)7 (10 mg/kg) and HS increases the pulmonary congestion in the animals

Ixabepilone 0160 It has minimal activity (IC50Ixabepilone (also known as azaepothilone B, or BMS 247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2 M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane