Tamibarotene - CAS# 94497-51-5 oxifen citrate thereby blocking VEGF-stimulated endothelial cell

thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability

functioning as an inhibitor of matrix metalloproteinases

5-c]pyridine-6-carboxylic acid

InChi: InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2

Tamibarotene - CAS# 94497-51-5 oxifen citrate thereby blocking VEGF-stimulated endothelial cellTamibarotene, also known as SY 1425, is an orally active, synthetic retinoid, developed to overcome all trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL 60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular