SB-222200 Size:Solid 10 mg Smiles: CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1O[C@@H]1COCC1

Smiles: CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1O[C@@H]1COCC1

Epub 2015 Sep 8

studies performed in vivo show that orally administered chrysin does not have clinical activity as an aromatase inhibitor

Synthesis and in vivo evaluationof novel quinoline derivatives as phosphodiesterase 10A inhibitors

SB-222200 Size:Solid 10 mg Smiles: CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1O[C@@H]1COCC1SB 222200 is a central nervous system penetrant, potent and selective NK 3 receptor antagonist. SB 222200 inhibited (125)I [MePhe(7)]neurokinin B (NKB) binding to Chinese hamster ovary (CHO) cell membranes stably expressing the hNK 3 receptor (CHO hNK 3R) with a K(i) = 4. 4 nM and antagonized NKB induced Ca(2+) mobilization in HEK 293 cells stably expressing the hNK 3 receptor (HEK 293 hNK 3R) with an IC(50) = 18. 4 nM. SB 222200 was selective for hNK