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RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 Formula: C22H17N3O6

RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 Formula: C22H17N3O6

Name: RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 Formula: C22H17N3O6
Brand: firemistltd.co.uk
SKU: 34434822719
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SKU: 34434822719

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RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 Formula: C22H17N3O6RO4929097, CAS No. 847925 91 1, is a highly potent and selective secretase inhibitor with an IC50 ~4 nM. It can cause a dramatic reduction of the intracellular Notch level and lead to significantly decreased expression of the Notch transcriptional target genes, such as Hes1. It exhibits potent inhibitory activity of Notch signaling in tumor cells. Currently RO4929097 is in multiple phase I II clinical trials to treat cancer. Product information CAS

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Description

Formula: C22H17N3O6

Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma

Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1

1801747-11-4

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