TNKS1 Polyclonal Antibody, 20ul Microplate Mixer Mutations and deficiencies in peroxisomal

Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders

The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins

This gene is most abundantly expressed in testis

Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1

TNKS1 Polyclonal Antibody, 20ul Microplate Mixer Mutations and deficiencies in peroxisomalCatalytic activity: NAD(+) + (ADP D ribosyl)(n) acceptor = nicotinamide + (ADP D ribosyl)(n+1) acceptor.,May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4 GLUT4 vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.,PTM: ADP ribosylated ( auto).,PTM: Phosphorylated on serine residues by MAPK kinases upon insulin stimulation.,Contains 1 PARP catalytic