MCF2 Polyclonal Antibody, 20ul NGS Oligos Defects in this gene are

Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam

including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci

The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2

Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways

MCF2 Polyclonal Antibody, 20ul NGS Oligos Defects in this gene areThe oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.