SIRT1(Phospho-Ser549) Rabbit Polyclonal Antibody, 20ul Live Cell Imaging Mutations in this gene are

Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome

This gene product binds to and inactivates p38 and SAPK/JNK

It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling

Mutations in this gene have been associated with autism and Asperger syndrome

SIRT1(Phospho-Ser549) Rabbit Polyclonal Antibody, 20ul Live Cell Imaging Mutations in this gene areThis gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular