CALRL Polyclonal Antibody, 50ul Cell Function Analysis The encoded protein is required

The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage

It has been associated with multiple functions| including axon membrane trafficking| axonal homeostasis| mitophagy| adipose differentiation| and hematopoietic stem cell maintenance

Alternatively spliced transcript variants encoding different isoforms have been reported

Radial spokes| which are regularly spaced along cilia| sperm| and flagella axonemes| consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein

CALRL Polyclonal Antibody, 50ul Cell Function Analysis The encoded protein is requiredReceptor for calcitonin gene related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,Belongs to the G protein coupled receptor 2 family.,subunit: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.,tissue specificity: Predominantly expressed in the lung and heart.,