Phospho-Caldesmon (S759) Polyclonal Antibody, 20ul Roller Bottles Mutations in this gene are

Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome

Reduced expression of this protein has been implicated in cardiomyopathies

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Hirschsprung disease type 2

Phospho-Caldesmon (S759) Polyclonal Antibody, 20ul Roller Bottles Mutations in this gene areCALD1 (caldesmon 1) encodes a calmodulin and actin binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+) calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+) dependent inhibition of