Rb Polyclonal Antibody, 50ul[BT-AP07686] Vacuum Filter Mature human MEGF9 is 572

Mature human MEGF9 is 572 amino acids (aa) in length

This gene is aberrantly methylated in pancreatic cancer

The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export

this protein was able to induce pseudopodia formation

Rb Polyclonal Antibody, 50ul[BT-AP07686] Vacuum Filter Mature human MEGF9 is 572The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.