ET-1 Polyclonal Antibody, 100ul Cell Biology The protein encoded by VAMP4

The protein encoded by VAMP4 (vesicle associated membrane protein 4) is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family

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Mutations in this gene have been associated with geroderma osteodysplastica

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ET-1 Polyclonal Antibody, 100ul Cell Biology The protein encoded by VAMP4EDN1 encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.