PERK Monoclonal Antibody, 100ul In vitro Assessment The heterodimeric receptor is involved

The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis

May be a transcriptional repressor

Represses the transcription of a number of genes including gastrin and ornithine decarboxylase

A pseudogene located on chromosome 3 has been identified for EZR

PERK Monoclonal Antibody, 100ul In vitro Assessment The heterodimeric receptor is involvedThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in