SREBP-1 Polyclonal Antibody, 50ul[BT-AP08552] Apoptosis & Autophagy The protein encoded by MED14

The protein encoded by MED14 (mediator complex subunit 14) is a subunit of the CRSP (cofactor required for SP1 activation) complex

2010 [PubMed: 20933441])

Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression| and the zinc-fingers comprise the DNA binding domain

The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis

SREBP-1 Polyclonal Antibody, 50ul[BT-AP08552] Apoptosis & Autophagy The protein encoded by MED14SREBF1 encodes a transcription factor that binds to the sterol regulatory element 1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. Sterol regulatory element binding protein 1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by