Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 100ul Lysosome The secreted protein acidic and

The secreted protein acidic and cysteine rich is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape

May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development

It functions as a pattern recognition receptor for microbes and an adhesion molecule for neurons

They are expressed in nearly all cells

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 100ul Lysosome The secreted protein acidic andAlpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin