TRAP240 Polyclonal Antibody, 50ul[BT-AP09183] NGS Oligos The ubiquitously expressed protein has

The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation

suggesting potential negative regulation through interference with complex formation via intramolecular binding

Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy

A related pseudogene exists in chromosome 6

TRAP240 Polyclonal Antibody, 50ul[BT-AP09183] NGS Oligos The ubiquitously expressed protein hasMED13 (mediator complex subunit 13) encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre initiation complex.