DAB2 Rabbit Polyclonal Antibody, 50ul Cellular Cultivation & Health Management and has the dual functions
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DAB2 Rabbit Polyclonal Antibody, 50ul Cellular Cultivation & Health Management and has the dual functionsThis gene encodes a mitogen responsive phosphoprotein. It is expressed in normal ovarian epithelial cells but is down regulated or absent from ovarian carcinoma cell lines suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2 an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras) via its C terminal proline rich sequences and may thus modulate growth factor Ras
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