Rat Prostaglandin G/H Synthase 2, PTGS2 ELISA Kit, 96T In vitro Transcription This gene is located in

This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12

Mutations in this gene have been found in somatic sebaceous tumors

an hydrophobic stretch corresponding to a single pass transmembrane region

Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family

Rat Prostaglandin G/H Synthase 2, PTGS2 ELISA Kit, 96T In vitro Transcription This gene is located inDual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20: 4(n 6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2 series prostaglandins and thromboxanes.