GFAP(Phospho Ser38) Polyclonal Antibody, 20ul Pipette Controller Mutations in this gene have

Mutations in this gene have been associated with chronic granulomatous disease

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It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements

Functions cooperatively with CDC42 and Rac to generate additional structures

GFAP(Phospho Ser38) Polyclonal Antibody, 20ul Pipette Controller Mutations in this gene haveThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.