BMAL1 Polyclonal Antibody, 50ul Custom DNA Oligos The encoded protein is thought

The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53

plays a role in inflammatory responses through binding to the receptors CCR1

and the relief of torsional stress that occurs during DNA transcription and replication

Mutations in this gene have been associated with Parkinson disease-8

BMAL1 Polyclonal Antibody, 50ul Custom DNA Oligos The encoded protein is thoughtAryl hydrocarbon receptor nuclear translocator like protein 1 encoded by ARNTL is a basic helix loop helix protein that forms a heterodimer with CLOCK. This heterodimer binds E box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK ARNTL complexes.